Synthesis of alpha-hydroxy ketones

Details Synthesis of alpha-hydroxy ketones Synthesis of alpha-hydroxy ketones

1990-07-06

1992-02-11

Reamer, James H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

568312, C07C 4545

Patent

active

050877615

ABSTRACT:
This invention relates to a process for condensing aldehydes to alpha-hydroxyketones in a liquid system containing an aldehyde and an active condensation catalyst formed by the abstraction of HX from a thiazolium salt in which X is the anion. The reaction is carried out in the absence of a base (other than the active catalyst) and the anion X. The catalyst is rendered free of the undesirable base and the anion X because these are the cause of premature deactivation of the catalyst.

REFERENCES:
patent: 4301310 (1981-11-01), Wagner
patent: 4782186 (1988-11-01), Beevor
Gracey et al., Chem. Abst., vol. 111, #233473g (1989).
Tanaka et al., Chem. Abst., vol. 111, #136, 456W (1989).
European Search Report dated Feb. 13, 1990 for application number EP 90307663.6 which is the counterpart in Europe to the present application.
Matsumoto et al., J. Chem. Soc. Chem., Commun. (1983), pp. 171-172.

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