Synthesis of adipic acid from biomass-derived carbon sources

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing oxygen-containing organic compound

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435175, 435189, 435232, 4353201, 4352523, 43525233, 4351723, 536 232, 536 237, 935 60, 935 27, 935 72, C12P 744

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054879876

ABSTRACT:
A method is provided for producing adipic acid. The method comprises the steps of culturing a cell transformant capable of converting a carbon source to catechol for a period of time sufficient to convert said carbon source to catechol, biocatalytically converting the catechol to cis, cis-muconic acid using catechol 1,2-dioxygenase, and hydrogenating the cis, cis-muconic acid to produce adipic acid.
Also provided is a heterologous transformant of the host cell having an endangeous common pathway of aromatic amino acid biosynthesis. The heterologous transformant is characterized by the constitutive expression of structural genes encoding 3-dehydroshikimate dehydratase, protocatechuate decarboxylase, and catechol 1,2-dioxygenase.

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