Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing oxygen-containing organic compound
Patent
1993-09-16
1996-01-30
Low, Christopher S. F.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing oxygen-containing organic compound
435175, 435189, 435232, 4353201, 4352523, 43525233, 4351723, 536 232, 536 237, 935 60, 935 27, 935 72, C12P 744
Patent
active
054879876
ABSTRACT:
A method is provided for producing adipic acid. The method comprises the steps of culturing a cell transformant capable of converting a carbon source to catechol for a period of time sufficient to convert said carbon source to catechol, biocatalytically converting the catechol to cis, cis-muconic acid using catechol 1,2-dioxygenase, and hydrogenating the cis, cis-muconic acid to produce adipic acid.
Also provided is a heterologous transformant of the host cell having an endangeous common pathway of aromatic amino acid biosynthesis. The heterologous transformant is characterized by the constitutive expression of structural genes encoding 3-dehydroshikimate dehydratase, protocatechuate decarboxylase, and catechol 1,2-dioxygenase.
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Draths Karen M.
Frost John W.
Low Christopher S. F.
Purdue Research Foundation
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