Synthesis of A-ring synthon of...

Organic compounds -- part of the class 532-570 series – Organic compounds – Silicon containing

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C556S400000, C568S626000, C568S659000, C568S660000

Reexamination Certificate

active

06844461

ABSTRACT:
The present invention provides a method for the synthesis of an A-ring synthon phosphine oxide used in the preparation of 19-nor vitamin D compounds, and to novel synthetic intermediates formed during the synthesis. The new method prepares the phosphine oxide from (D)-glucose.

REFERENCES:
patent: 5086191 (1992-02-01), DeLuca et al.
patent: 5581006 (1996-12-01), DeLuca et al.
patent: 5936133 (1999-08-01), Deluca et al.
patent: 6683219 (2004-01-01), DeLuca et al.
CA:129:175887 abs of Tetrahedron Lett by Schmitt et al 39(27) p4817-4820 1998.*
CA:139:53208 abs of Bioorganic and Medicinal Chem Letters by Yoshinori et al 13(5) pp 809-812 2003.*
Abstract 122:81736; Sicinski et al; Synthesis and Biological Activity of 2-Hydroxy and 2-Alkoxy Analogs of 1Alpha,25-Dihydroxy-19-Norvitamin D3; Journal of Medicinal Chemistry; 1994, 37(22), 3730-8.
Abstract 127:359017; Kozikowski et al; Synthesis of 1D-3-Deoxy- and -2,3-Dideoxyphosphatidylinositol; Tetrahedron; 1997 , 53(44), 14903-14914.
Abstract 114:7016; Cambie et al; A Stereocontrolled Synthesis of Proto-Quercitol; Australian Journal of Chemistry; 1990, 43(9), 1597-602.
Abstract 115:92747; Baker et al; Design and Synthesis of 6Alpha-Substituted-2Beta-Phosphoryloxycyclohexanes, Potent Inhibitors of Inositol Monophosphatase; Journal of the Chemical Society, Chemical Communications; 1991, (5), 298-300.
Abstract 130:263914; Iwase et al; Bioscience, Biotechnology, and Biochemistry; 1998, 62(12), 2396-2407.
Abstract 96:163074; Yoshikawa et al; Heterocycles, 1982, 17 (Spec. Issue), 209-14.
Sicinski et al; New 1Alpha,25-Dihydroxy-19-Norvitamin D3 Compounds of High Biological Activity: Synthesis and Biological Evaluation of 2-Hydroxymethyl, 2-Methyl, and 2-Methylene Analogues; Journal of Medicinal Chemistry; 1998, (41), 4662-4674.
Posner et al; Stereocontrolled Synthesis of a Trihydroxylated A Ring as an Immediate Precursor to 1Alpha,2Alpha,25-Trihydroxyvitamin D3; Journal of Organic Chemistry; 1991, (56), 4339-4341.
Perlman et al; 1Alpha,25-Dihydroxy-19-Nor-Vitamin D3, A Novel Vitamin D-Related Compound with Potential Therapeutic Activity; Tetrahedron Letters, 1990, (31), 13, 1823-1824.
Perlman et al; Novel Synthesis of 19-Nor-Vitamin D Compounds; Tetrahedron Letters, 1991, (32), 52, 7663-7666.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Synthesis of A-ring synthon of... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Synthesis of A-ring synthon of..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Synthesis of A-ring synthon of... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3395772

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.