Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 11 to 14 amino acid residues in defined sequence
Reexamination Certificate
2007-03-20
2007-03-20
Campell, Bruce R. (Department: 1654)
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
11 to 14 amino acid residues in defined sequence
Reexamination Certificate
active
10168391
ABSTRACT:
The present invention refers to the chemical synthesis and potentiality for application in several biochemical assays, of a potent agonist of the α-melanocyte stimulating hormone (α-MSH), labeled with an amino acid-type paramagnetic spin probe (Toac, or 2,2,6,6-tetramethylpiperidine-1-oxyl-amino-4-carboxylic acid), valuable for use in electron spin resonance and fluorescence allowing biochemical-clinical investigation of relevant physiological roles of α-MSH in animal organism. The referred analogue of the present invention, acetil-Toac0-(Nle4, DPhe7)-α-MSH, where (Nle4, DPhe7)-α-MSH is nominated commercially as Melanotan™ and although containing a non-natural compound in its structure such as Toac, maintained entirely its potent agonist potency. Its integral activity associated with the fact that it is naturally fluorescent (due to the Trp residue of its sequence) give to this labeled analogue a unique potential for a great variety of investigations regarding relevant physiological roles already known of this neuroimmuno-modulator.
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Barbosa Simone Dos Reis
Castrucci Ana Maria De Lauro
Cilli Eduardo Maffud
Lamy-Freund Maria Tereza
Nakaie Clovis Ryuichi
Campell Bruce R.
Conselho Nacional de Desenvolvimento Cientifico E Technologico-C
Morrison & Foerster / LLP
Teller Roy
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