Synthesis of a derivative of GRF and intermediate peptides

Details Synthesis of a derivative of GRF and intermediate peptides Synthesis of a derivative of GRF and intermediate peptides

1987-11-09

1988-09-27

Phillips, Delbert R.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

530326, 530325, 530327, 530328, 530329, C07K 706, C07K 708, C07K 710

Patent

active

047743190

ABSTRACT:
A process for the manufacture of a polypeptide (I) having the formula: ##STR1## which comprises steps of: (a) coupling, successively and in the order of the sequence of the polypeptide (I), the four protected fragments A, B, C and D or five protected fragments A, B, C, E and F,

REFERENCES:
patent: 4581168 (1986-04-01), Diaz et al.
Nature, 300, pp. 276-278 (1981).
Chem. Pharm. Bull., 32, pp. 510-519 (1984).
Chem. Pharm. Bull., 32, pp. 520-529 (1984).
J. Takeda Res. Lab., 42, pp. 209-226 (1983).
Peptide Chemistry, pp. 285-290 (1983).
Int. J. Peptide Protein Res., 24, pp. 498-504 (1984).

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