Synthesis of a benzoxazinone

Details Synthesis of a benzoxazinone Synthesis of a benzoxazinone

2007-04-17

2007-04-17

Habte, Kahsay (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

C544S090000

Reexamination Certificate

active

11217892

ABSTRACT:
The present invention provides novel methods for the synthesis of (S)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one of formula (III)which is useful as a human immunodeficiency virus (HIV) reverse transcriptase inhibitor.

REFERENCES:
patent: 5922864 (1999-07-01), Frey et al.
Pierce et al. J. Org. Chem. 1998, 63, 8536-8543.
Pierce et al., “Practical Asymmetric Synthesis of Efavirenz (DMP 266), and HIV-1 Reverse Transcriptase Inhibitor”, J. Org. Chem., vol. 63, p. 8536-8543, 1998.
Radesca et al., “Synthesis of HIV-1 Reverse Transcriptase Inhibitor DMP 266”, Synthetic Communications, vol. 27(24), pp. 4373-4384, 1997.

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