Organic compounds -- part of the class 532-570 series – Organic compounds – Chalcogen bonded directly to ring carbon of the purine ring...
Patent
1993-04-07
1994-07-12
Berch, Mark L.
Organic compounds -- part of the class 532-570 series
Organic compounds
Chalcogen bonded directly to ring carbon of the purine ring...
544265, 544277, C07D47318, C07B 3508
Patent
active
053290089
ABSTRACT:
Synthesis of the triol of the following formula (I) from an alcohol of the formula (IV): ##STR1## via steps including protecting and then cyanating the alcohol to yield a cyanide, isomerization of the double bond, hydrolysis followed by reduction of the cyanide back to an alcohol and cis-dihydroxylation of the double bond.
REFERENCES:
patent: 4621140 (1986-11-01), Verheyden et al.
patent: 4742064 (1988-05-01), Vince
patent: 4774325 (1988-09-01), Casadio et al.
patent: 5110926 (1992-05-01), Storer
patent: 5126452 (1992-06-01), Vince
patent: 5155112 (1992-10-01), Storer et al.
patent: 5233041 (1993-08-01), Bray
Schroder, et al, "Osmium Tetraoxide Cis Hydroxylation of Unsaturated Substrates" Chem. Rev., 80, 187-213 (1980).
Geiger, et al, Peptides, 3, 1-2 (1981).
Van Rheenen, et al, "Catalytic Osmium Tetroxide Oxidation of Olefins: cis-1,2-Cyclohexanediol", Org. Synth., 58, 43-52 (1978 Eng.).
Behr, et al, "Structure Elucidation and Synthesis of 3,3-Dimethyl-7-hydroxy-2-octanone, a New Seco Nor-carotenoid Constituent of Greek Tobacco", Acta Chemica Scandinavica, B 31, 793-796 (1977).
Bray Brian L.
Partridge John J.
Berch Mark L.
Glaxo Inc.
Smith Gardiner F. H.
LandOfFree
Synthesis of a 3,4-dihydroxy-1-cyclopentanylpurinone does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Synthesis of a 3,4-dihydroxy-1-cyclopentanylpurinone, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Synthesis of a 3,4-dihydroxy-1-cyclopentanylpurinone will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-397475