Synthesis of 6-methylene derivatives of androsta-1,4-diene-3,17-

Details Synthesis of 6-methylene derivatives of androsta-1,4-diene-3,17- Synthesis of 6-methylene derivatives of androsta-1,4-diene-3,17-

1989-01-06

1990-11-13

Gerstl, Robert

Organic compounds -- part of the class 532-570 series

Organic compounds

Cyclopentanohydrophenanthrene ring system containing

C07J 100

Patent

active

049703277

ABSTRACT:
The invention relates to a new process for the preparation of know aromatase inhibitors of the following formula (I) ##STR1## wherein each of R.sub.1 R.sub.3, independently, is hydrogen or C.sub.1 -C.sub.6 alkyl;

REFERENCES:
patent: 3112305 (1963-11-01), Kirk
patent: 3356694 (1967-05-01), None
patent: 4322349 (1982-03-01), Annen et al.
patent: 4416821 (1983-11-01), VanRheenen
patent: 4512986 (1985-04-01), Reel et al.
patent: 4808616 (1989-02-01), Buzzetti
Carey and Sundbert, Advanced organic Chemistry, 2nd Ed. Part B, pp. 44-46 (1983).
Annen et al, Synthesis, 1: 34-40, 1982.
Annen, Klaus et al. "A Simple Method for 6-Methylenation of 3-Oxo-.DELTA..sup.4 -steroids", Synthesis, pp. 34-41.
Burn, D. et al. "Modified Steroid Hormones-XXXIII.sup.1 ; Steroidal 6-Formyl-3-Alkoxy-3,5-Dienes and Some of Their Transformations", Tetrahedron, vol. 20, (1964), pp. 597-609.

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