Drug – bio-affecting and body treating compositions – Conjugate or complex of monoclonal or polyclonal antibody,... – Conjugated via claimed linking group – bond – chelating agent,...
Patent
1977-06-08
1978-10-31
Brown, Johnnie R.
Drug, bio-affecting and body treating compositions
Conjugate or complex of monoclonal or polyclonal antibody,...
Conjugated via claimed linking group, bond, chelating agent,...
536 28, 536 26, 536 27, 536 24, 536 23, 536 29, A61K 3170, C07H 1902
Patent
active
041235240
ABSTRACT:
The compound 6-amino-4-methyl-8-(.beta.-D-ribofuranosyl)pyrrolo[4,3,2-de]pyrimido[4,5-c ]pyridazines-5'-phosphate (a nucleotide) as a new compound and its method of synthesis by phosphorylation of the known 6-amino-4-methyl-8-(.beta.-D-ribofuranosyl)pyrrolo[4,3,2-de]pyrimido[4,5-c ]pyridazine (a nucleoside). The 5'-phosphate ester has utility against L-1210 mouse leukemia and has superior solubility over the parent compound which gives it a broader use pattern relative to dosage. This novel nucleotide also shows advantage in utilization as to pH over, for example, the hydrochloride salt which gives in solution a pH of 4 and is too acid for use.
REFERENCES:
patent: 3413282 (1968-11-01), Yoshikawa et al.
Towsend, L. and Schram, K., Tetrahedron Letter, 1971, No. 49, pp. 4757-4760.
Lewis Arthur F.
Roti Roti Linda W.
Townsend Leroy B.
Brown Johnnie R.
Ferris Thomas G.
Hazel Blondel
Latker Norman J.
Roberts, Jr. John S.
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