Synthesis of 6.alpha.-functionalized estriol haptens and protein

Details Synthesis of 6.alpha.-functionalized estriol haptens and protein Synthesis of 6.alpha.-functionalized estriol haptens and protein

1997-11-14

1999-05-11

Hutzell, Paula K.

Organic compounds -- part of the class 532-570 series

Organic compounds

Cyclopentanohydrophenanthrene ring system containing

540106, C07D301/27

Patent

active

059028882

ABSTRACT:
Disclosed are 6.alpha.-derivatized estriol compounds which, when conjugated to a protein, are useful in the in vivo preparation of antibodies specific to estriol. When labeled with a detectable label, the estriol derivatives are useful as haptens in a competitive immunoassay for estriol which demonstrate superior sensitivity with respect to estriol specific antibodies.

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Nambara et al, Chem. Pharm. Bull., 22 (5), 1167-1173 (1974).
Longwell et al, Biol. Chem., 133 219-229 (1940).
Smith et al, J. Org. Chem., 37 (25) 4000-4002 (1972).
Jeffcoate et al, Steroids, 19 (2) 181-188 (1972).
Dean et al, Steroids, 593-603 (1971).

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