Synthesis of 6-(2-hydroxyphenyl)-3(2H)-pyridazinones from trihal

Details Synthesis of 6-(2-hydroxyphenyl)-3(2H)-pyridazinones from trihal Synthesis of 6-(2-hydroxyphenyl)-3(2H)-pyridazinones from trihal

1977-10-19

1979-05-01

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

26034673, 260566B, 260590R, 548378, C07D23714

Patent

active

041525175

ABSTRACT:
A new synthesis for the preparation of 6-(2-hydroxyphenyl)-3-pyridazinones whose key reaction is cyclizing a 1,1,1-trihalo-2-hydroxy-4-(2-hydroxyphenyl)-1-butanone with hydrazine. 6-(2-Hydroxyphenyl)-3-pyridazinones are important intermediates for preparing medicinally active compounds.

REFERENCES:
Y. Y. Lee et al., J. Korean Chem. Soc. 17, 25 (1973).

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