Synthesis of 5-azacytidine

Details Synthesis of 5-azacytidine Synthesis of 5-azacytidine

2008-09-10

2010-12-28

Jiang, Shaojia Anna (Department: 1623)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C536S028200, C514S043000

Reexamination Certificate

active

07858774

ABSTRACT:
The present invention provides a method for the preparation of 5-azacytidine, wherein 5-azacytidine is represented by the structure:The method involves the silylation of 5-azacytosine, followed by the coupling of silylated 5-azacytosine to a protected β-D-ribofuranose derivative. The coupling reaction is catalyzed by trimethylsilyl trifluoromethanesulfonate (TMS-Triflate).

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