Synthesis of (4S, 5R) -2, 4-diphenyl-5-carboxy-oxazoline derivat

Details Synthesis of (4S, 5R) -2, 4-diphenyl-5-carboxy-oxazoline derivat Synthesis of (4S, 5R) -2, 4-diphenyl-5-carboxy-oxazoline derivat

1996-06-14

1998-06-30

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549510, C07D26316

Patent

active

057736294

ABSTRACT:
The present invention provides a process for preparing a (4S,5R)-2,4-diphenyl-5-carboxy-oxazoline derivative, which can serve as a taxol side-chain precursor, from the treatment of a (2R,3S)-alkyl trans-3-phenyl-2,3-epoxypropionate derivative with benzonitrile in the presence of a strong acid.

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