Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acids and salts thereof
Patent
1992-04-13
1994-03-08
Shippen, Michael L.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carboxylic acids and salts thereof
5303915, 564217, 558 17, C07C 6108
Patent
active
052929388
ABSTRACT:
Cyclo agents useful in forming antibody-metal conjugates useful for diagnostic and therapeutic purposes. New compounds and processes of forming these compounds are disclosed including 4-haloacetamido-trans-1,2-diaminocyclohexyl polyaminocarboxylate and 4-isothiocyanato-trans-1,2-diamino cyclohexane-N,N,N',N'-tetra acetic acid.
REFERENCES:
patent: 2519708 (1950-08-01), Schlapfer
patent: 5021571 (1991-06-01), Mease et al.
patent: 5089663 (1992-02-01), Mease et al.
Mease, Supplement to J. Nucl. Med. 32, p. 1023 abstract No. 482. (May, 1991).
Witiak et al., "Stereocontrolled Syntheses for the Six Diastereomeric 1,2-Dihydroxy-4,5-diaminocyclohexanes: Pt.sup.II Complexes and P-388 Antitumor Properties", J. Med. Chem., 30, pp. 1327-1336, 1987.
Srivastava, et al., "CDTA-In-111-Anti-CEA F(ab').sub.2 Immunoconjugates Produce Improved Biodistribution and Better Images in Nude Tumor Mice", J. Nucl. Med., 32, p. 1023, 1991.
Mease, et al., "Effect of Chelate Rigidity On In Vivo Radioimmunoconjugate Distribution", J. Label. Comp. Radiopharm., 30, p. 319, 1991.
Mausner Leonard F.
Mease Ronnie C.
Srivastava Suresh C.
Associated Universities Inc.
Bogosian Margaret C.
Shippen Michael L.
LandOfFree
Synthesis of 4-substituted-trans-1, 2-diaminocyclohexyl polyamin does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Synthesis of 4-substituted-trans-1, 2-diaminocyclohexyl polyamin, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Synthesis of 4-substituted-trans-1, 2-diaminocyclohexyl polyamin will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-155104