Package making – Closing packages and filled receptacles – Separate closure applying
Patent
1994-08-05
1996-09-17
Kunz, Gary L.
Package making
Closing packages and filled receptacles
Separate closure applying
536 185, 536 186, 536 53, C07H 100
Patent
active
055569633
ABSTRACT:
This invention relates to an improved process for the synthesis of 4-alkoxy-N-acetylneuraminic acids. According to the process of the invention, N-acetylneuraminic acid is first alkylated at C-1 and C-2 and then the vicinal hydroxyl groups at C-8 and C-9 are protected through the formation of a ketal. The resulting protected alkyl ester alkyl ketoside is then alkylated at the C-4 position whereby the hydrogen of the C-4 hydroxyl group is replaced with an alkyl group to form an alkoxy group. Deprotection is accomplished through the removal of the ketal group at C-8 and C-9 and removal of the alkyl groups at C-1 and C-2, thereby producing the 4-alkoxy-N-acetylneuraminic acid.
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Blystone Sheri
Hardgrave Ragen F.
Liav Avraham
Turner Gregory A.
Fonda Kathleen Kahler
Kunz Gary L.
Oklahoma Medical Research Foundation
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