Synthesis of 4-alkoxy-5-fluoro-2'-deoxyuridine and its incorpora

Details Synthesis of 4-alkoxy-5-fluoro-2'-deoxyuridine and its incorpora Synthesis of 4-alkoxy-5-fluoro-2'-deoxyuridine and its incorpora

1996-03-12

1997-09-02

Kunz, Gary L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 253, C07H 100, C07H 102

Patent

active

056633238

ABSTRACT:
A synthesis of 5-fluoro-2'-ideoxycytidine, of oligonucleotides containing 5-fluoro-2'-deoxycytidine and of certain novel 4-alkoxy-5-fluoro-2'-deoxyuridines is disclosed. These 4-alkoxy compounds are useful intermediates for the preparation of other 4-substituted, 5-fluoro pyrimidine deoxynucleosides, and spontaneously hydrolyze in target cells to form FdU and derivatives thereof.

REFERENCES:
patent: 3404144 (1968-10-01), Fox et al.
patent: 4754026 (1988-06-01), Kawada et al.
Divakar, et al., J. Chem. Soc. Perkin Trans., pp. 1171-1176, 1982.
Chemical Abstracts, vol. 97, No. 7., Abstract No. 56191h, p. 690, 1982, Funai Pharmaceutical Industries, Ltd., Japan Kokai JP 82 28.083.
Martin et al., J. Pharm. Sci., 76(2):1 180-184, 1987.
Sowers et al., J. Biol. Chem., 263(29): 14794-14801 (1988).

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