Synthesis of 3-deazapurines

Details Synthesis of 3-deazapurines Synthesis of 3-deazapurines

1998-05-08

1999-09-07

Wilson, James O.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 2533, 536 267, 536 2713, 536 273, 536 276, 536 277, 544242, 544245, 544253, 544278, 544279, 546118, C07H 1904, C07H 2100

Patent

active

059489030

ABSTRACT:
This invention relates to compounds based on the 3-deazapurines ring system and to methods for making such compounds. The invention also generally relates to the field of "antisense" agents, agents that are capable of specific hybridization with a nucleotide sequence of an RNA. The 3-deazapurine-containing compounds of this invention can be useful for modulating the activity of RNA when incorporated into oligonucleotides. Oligonucleotides and their analogs are used for a variety of therapeutic and diagnostic purposes, such as treating diseases, regulating gene expression in experimental systems, assaying for RNA and for RNA products through the employment of antisense interactions with such RNA, diagnosing diseases, modulating the production of proteins and cleaving RNA in site specific fashions.

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