Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acid esters
Reexamination Certificate
2010-05-12
2011-10-11
Sullivan, Daniel (Department: 1621)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carboxylic acid esters
Reexamination Certificate
active
08034969
ABSTRACT:
N—[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester is produced by hydrogenation of L-α-aspartyl-L-phenylalanine 1-methyl ester and 3,3-dimethylbutyraldehyde produced in situ by the hydrolysis or cleavage of a 3,3-dimethylbutyraldehyde precursor. The production method is efficient and low cost, as compared with conventional N—[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester synthesis.
REFERENCES:
patent: 5480668 (1996-01-01), Nofre et al.
patent: 5510508 (1996-04-01), Claude et al.
patent: 5728862 (1998-03-01), Prakash
patent: 5905175 (1999-05-01), Guo et al.
patent: 6423864 (2002-07-01), Prakash et al.
patent: 6548096 (2003-04-01), Amino et al.
patent: 6642406 (2003-11-01), Prakash et al.
patent: 6720446 (2004-04-01), Scaros et al.
patent: 00/15656 (2000-03-01), None
patent: 01/02332 (2001-01-01), None
T.W. Greene, et al., Protective Groups in Organic Synthesis, John Wiley & Sons, Inc., New York, chapter 4, pp. 175-179 and 212-217 (1991).
K. B. Wiberg, et al. “Thermochemical Studies of Carbonyl Reactions. 2. Steric Effects in Acetal and Ketal Hydrolysis”, J. Am. Chem. Soc., vol. 103, pp. 4473-4478 (1981).
Database Crossfire Beilstein Online, Beilstein Institute for Organic Chemistry, Frankfurt-Main, Germany, database accession No. 2810842 (RID) XP002293793, abstract, 1981.
D. R. Larkin, J. Org. Chem., vol. 55, pp. 1563-1568 (1990).
J. A. Ragan, et al., “Safe Execution of a Large-Scale Ozonolysis”, Organic Proc. Res. And Dev., vol. 7, No. 2, pp. 155-160 (2003).
Furlong Kenneth E.
Jackson, III Handley E.
Prakash Indra
Fitzpatrick ,Cella, Harper & Scinto
Sullivan Daniel
The NutraSweet Company
Valenrod Yevegeny
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