Synthesis of 2-pyridylalkylamines

Details Synthesis of 2-pyridylalkylamines Synthesis of 2-pyridylalkylamines

1983-03-22

1985-07-02

Jiles, Henry R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546296, 546297, 546300, 546304, 546307, 546311, C07D21338

Patent

active

045269742

ABSTRACT:
The invention provides a process for preparing 2-pyridylalkylamines by reacting an alkali metal derivative of a 2-methylpyridine with a haloalkylamine. The compounds are useful as intermediates in the preparation of compounds having histamine H.sub.1 - and H.sub.2 -antagonist activity.

REFERENCES:
patent: 4154834 (1979-05-01), Brown et al.
patent: 4255428 (1981-03-01), Brown et al.
Vaughan et al., J. Org. Chem., 26, pp. 138-144, (1961).
Raynolds et al., J. Am. Chem. Soc., 82:1152-5, (1960).
Klingsberg, E. ed., "The Chemistry of Heterocyclic Compounds, Pyridine and Its Derivatives," Part Three, p. 71, (John Wiley & Sons, 1963).
Chemical Abstracts, 63:584c, (1965).
Marion et al., J. Am. Chem. Soc., 71:3402-4, (1949).
Kyte et al., J. Chem. Soc., 4454-4472, (1960).

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