Synthesis of 2-isopropylamino-pyrimidine

Details Synthesis of 2-isopropylamino-pyrimidine Synthesis of 2-isopropylamino-pyrimidine

1980-06-23

1981-05-05

Coughlan, Jr., Paul M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544318, C07D23942

Patent

active

042660580

ABSTRACT:
The present invention provides a process for the synthesis of 2-isopropylamino-pyrimidine by aminolysis of 2-methylsulphonyl-pyrimidine using isopropylamine. The aminolysis is effected, according to the present invention, by refluxing isopropylamine and 2-methylsulphonyl-pyrimidine in the absence of a solvent. Using this technique, the 2-isopropylamino-pyrimidine has been obtained in a substantially quantitative yield.

REFERENCES:
patent: 2586844 (1952-02-01), McKay et al.
patent: 4116674 (1978-09-01), Sunley et al.
Brown, The Pyrimidines, pub. by Interscience (1962), pp. 298-300.

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