Synthesis of 2-chloromethyl-6-methylbenzoic ester

Details Synthesis of 2-chloromethyl-6-methylbenzoic ester Synthesis of 2-chloromethyl-6-methylbenzoic ester

2006-01-24

2006-01-24

Price, Elvis O. (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

C560S008000, C560S106000, C560S107000, C560S108000, C560S110000, C560S111000, C560S112000, C560S113000, C562S405000, C562S493000

Reexamination Certificate

active

06989462

ABSTRACT:
A process is described for preparing compounds of formula (I)where R is H, optionally halogen-substituted alkyl, cycloalkyl, aryl, alkyl-aryl or heteroaryl, and, in alkyl and cycloalkyl, one or more CH2groups may be replaced by —O—. The compounds of the formula (I) are valuable intermediates in the synthesis of PPAR agonists.

REFERENCES:
patent: 4585788 (1986-04-01), Helsley et al.
patent: WO 00/64876 (2000-11-01), None
patent: WO 00/64888 (2000-11-01), None
patent: WO 03/020269 (2003-03-01), None
Tilstam Ulf et al., Trichloroisocyanuric Acid: A Safe and Efficient Oxidant, Org Process Research & Development, vol. 6, 2002, pp 384-393.

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