Synthesis of 2-alkyl amino acids

Details Synthesis of 2-alkyl amino acids Synthesis of 2-alkyl amino acids

2006-05-02

2006-05-02

Solola, Taofiq (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

C560S012000, C560S019000

Reexamination Certificate

active

07038073

ABSTRACT:
A method of preparing a 2-alkyl amino acid involves the aziridination of an alkylacrylate and the opening of the aziridine ring by addition of a side chain. This method can result in the preparation of enantiomeric excess of a 2-alkyl amino acid. The invention also discloses a method of preparing a class of iron chelating agents related to desferrithiocin, all of which contain a thiazoline ring. In this method, an aryl nitrile or imidate is condensed with cysteine, a 2-alkyl cysteine, or a cysteine ester.

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