Synthesis of 2-acyl substituted chromanes and intermediates...

Details Synthesis of 2-acyl substituted chromanes and intermediates... Synthesis of 2-acyl substituted chromanes and intermediates...

2005-06-07

2005-06-07

Powers, Fiona T. (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C435S125000

Reexamination Certificate

active

06903227

ABSTRACT:
Novel processes for producing enantiomerically enriched and enantiomerically pure compositions of 2-acyl substituted chromane compounds, and 2-acylchromane compounds that are intermediates for producing platelet aggregation inhibitors and/or are themselves potent platelet aggregation inhibitors are disclosed. Further disclosed are processes for producing salts such as acid addition salts for such enantiomerically enriched compositions.

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R.E. Mewshaw, et al., “New Generation Dopaminergic Agents 4. Exploiting the 2-Methyl Chroman Scaffold. Synthesis and Evaluation of Two Novel Series of 2-(Aminomethyl)-3,4,7,9-tetrahydro-2H-pyrano [2,3-e] indole and Indol-8-one Derivatives,”Tetrahedron, vol. 54, 1998, pp. 7081-7108, 1998.
R.E. Mewshaw, et al., “New Generation Dopaminergic Agents 1. Discovery of a Novel Scaffold Which Embraces the D2Agonist Pharmacophore. Structure—Activity Relationships of a Series of 2-(Aminomethyl) Chromans,”J. Med. Chem, 1997, vol. 40, pp. 4235-4256.

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