Synthesis of 2-(4-aminophenoxy)alkanoic acids and esters and the

Details Synthesis of 2-(4-aminophenoxy)alkanoic acids and esters and the Synthesis of 2-(4-aminophenoxy)alkanoic acids and esters and the

1988-03-21

1989-11-28

Gray, Bruce

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

260404, 2604045, 558 47, 558 48, 558 49, 558 50, 558413, 558414, 558415, 562430, 562435, 562437, 562440, 562455, C07C10172

Patent

active

048839019

ABSTRACT:
A method for synthesizing 2-(4-amidophenoxy)alkanoic acids and esters and 2-(4-aminophenoxy)alkanoic acids and esters by reacting a hydroxyaromatic ketone derivative with a 2-substituted alkanoic acid or ester under basic conditions and thereafter reacting with a hydroxylamine derivative and conducting a Beckmann Rearrangement in the presence of a catalyst with subsequent solvolysis.

REFERENCES:
patent: 3081302 (1963-03-01), Shapiro et al.
patent: 3278524 (1966-10-01), Johnson et al.
patent: 4358307 (1982-11-01), Serban et al.
patent: 4439226 (1984-03-01), Pilgram
Chemical Abstracts, vol. 59, No. 5080, Substituted Propionic Acids as Anti-Inflammatory Agents, (British Patent) 916,242, (1963).
Journal of Organic Chemistry, Smiles Rearrangement on Borohydride Reduction of a Nitrophenoxy Ester, M. Harefenist, et al., vol. 36, No. 9, (1971).

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