Synthesis of 2-(2-furoyl)-4(5)-(2-furanyl)-1H-imidazole and anal

Details Synthesis of 2-(2-furoyl)-4(5)-(2-furanyl)-1H-imidazole and anal Synthesis of 2-(2-furoyl)-4(5)-(2-furanyl)-1H-imidazole and anal

1997-08-06

1999-01-05

McKane, Joseph K.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D40714

Patent

active

058565116

ABSTRACT:
The present invention relates to a practical and facile synthesis of 2-(2-furoyl)-4(5)-(2-furanyl)-1H-imidazole (FFI) and analogs thereof. The synthesis utilized a novel hydrazinium salt as an intermediate reaction product which facilitates the isolation of purified product in high yields.

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Arcorta et al., 1975, J. Het. Chem., 12:215.
Bucala et al., 1992, Advances in Pharmacology, 23:1-34.
Chang et al, 1985, J. Biol. Chem., 260:1970-4.
Dubac et al.,1991, Synth. Commun., 21:11.
Maillard et al., 1912, C.R. Acad. Sci., 154-66-8.

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