Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acid esters
Reexamination Certificate
2007-10-30
2007-10-30
Richter, Johann R. (Department: 1621)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carboxylic acid esters
Reexamination Certificate
active
10834933
ABSTRACT:
N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester is produced by hydrogenation of L-α-aspartyl-L-phenylalanine 1-methyl ester and 3,3-dimethylbutyraldehyde produced in situ by the hydrolysis or cleavage of a 3,3-dimethylbutyraldehyde precursor. The production method is efficient and low cost, as compared with conventional N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester synthesis.
REFERENCES:
patent: 5480668 (1996-01-01), Nofre et al.
patent: 5510508 (1996-04-01), Claude et al.
patent: 5728862 (1998-03-01), Prakash
patent: 5905175 (1999-05-01), Guo et al.
patent: 6423864 (2002-07-01), Prakash et al.
patent: 6548096 (2003-04-01), Amino et al.
patent: 6642406 (2003-11-01), Prakash et al.
patent: 6720446 (2004-04-01), Scaros et al.
patent: 00/15656 (2000-03-01), None
patent: 01/02332 (2001-01-01), None
Larkin D. R. Journal of Organic Chemistry 1990, 55, 1563-1568.
T. W. Greene, et al., Protective Groups in Organic Synthesis, John Wiley & Sons, Inc., New York, chapter 4, pp. 175-179 and 212-217(1991).
K. B. Wiberg, et al., “Thermochemical Studies of Carbonyl Reactions. 2. Steric Effects in Acetal and Ketal Hydrolysis”, J. Am. Chem. Soc., vol. 103, pp. 4473-4478 (1981).
Database Crossfire Beilstein Online, Beilstein Institute for Organic Chemistry, Frankfurt-Main, Germany, database accession No. 2810842 (RID) XP002293793, abstract, 1981.
Furlong Kenneth E.
Jackson, III Handley E.
Prakash Indra
Fitzpatrick ,Cella, Harper & Scinto
Richter Johann R.
The Nutrasweet Company
Yevgeny Valenrod
LandOfFree
Synthesis of... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Synthesis of..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Synthesis of... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3891947