Synthesis of [ 13 C] and [ 2 H] substituted methacrylic...

Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acids and salts thereof

Reexamination Certificate

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C562S426000, C562S429000, C560S009000, C560S011000

Reexamination Certificate

active

07662993

ABSTRACT:
The present invention is directed to labeled compounds of the formulaewherein Q is selected from the group consisting of —S(═O)—, and —S(═O)2—, Z is selected from the group consisting of 1-naphthyl, substituted 1-naphthyl, 2-naphthyl, substituted 2-naphthyl, and phenyl groups with the structurewherein R1, R2, R3, R4and R5are each independently selected from the group consisting of hydrogen, a C1-C4lower alkyl, a halogen, and an amino group selected from the group consisting of NH2, NHR and NRR′ where R and R′ are each independently selected from the group consisting of a C1-C4lower alkyl, an aryl, and an alkoxy group, and X is selected from the group consisting of hydrogen, a C1-C4lower alkyl group, and a fully-deuterated C1-C4lower alkyl group.

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Spinelli et al., “On the Reaction of 3-Bromo-2nitrobenzo[b]thiophene13C-Labeled at C-2 with 3-(Trifluoromethyl)aniline: A Preliminary Insight into a Nucleophilic Substitution with Rearrangement,” J. Org. Chem 1997, 62, 4921-4923, (1997).

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