Synthesis of...

Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acid esters

Reexamination Certificate

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C548S232000

Reexamination Certificate

active

06852875

ABSTRACT:
Synthesis of N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester by treating N-(3,3-dimethylbutyl)-L-aspartic acid with ketones to give oxazolidinone derivatives, which are condensed with L-phenylalanine methyl ester.

REFERENCES:
patent: 5480668 (1996-01-01), Nofre et al.
patent: 5510508 (1996-04-01), Claude et al.
patent: 5728862 (1998-03-01), Prakash
patent: 6077962 (2000-06-01), Prakash et al.
patent: 1174844 (1998-03-01), None
patent: 0015656 (2000-03-01), None
Burger et al, Regiospecific Reactions with Omega-Carboxy-Alpha-Amino Acids. A Simple Synthesis of Aspartame., Chemmiker Zeitlung 1990, 114(7-8), pp. 249-251.

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