Synthesis of 1-substituted isoquinolines

Details Synthesis of 1-substituted isoquinolines Synthesis of 1-substituted isoquinolines

1982-01-28

1985-04-30

Hollrah, Glennon H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546 14, 546 21, 546 44, 546 74, 546139, 546144, C07D21720

Patent

active

045145695

ABSTRACT:
A method for the synthesis of particular isoquinoline compounds which are useful intermediates in the preparation of members of the family of opium alkaloids, such as morphine and codeine. Steps in the process include the acylation of the isoquinoline nitrogen; reaction of the acylated isoquinoline with a phosphorous compound; and condensation with a benzaldehyde derivative to yield a 1-benzyl isoquinoline.

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Akiba, et al., "Tetrahedron Letters", vol. 22, No. 49, 1981, pp. 4977-4980.

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