Synthesis of 1.alpha.-hydroxy-secosterol compounds

Details Synthesis of 1.alpha.-hydroxy-secosterol compounds Synthesis of 1.alpha.-hydroxy-secosterol compounds

1991-03-11

1992-02-18

Mars, Howard T.

Organic compounds -- part of the class 532-570 series

Organic compounds

9,10-seco-cyclopentanohydrophenanthrene ring system or...

C07C 7500

Patent

active

050896415

ABSTRACT:
This invention provides a new method of making secosterol compounds, and in particular to the preparation of 1.alpha.-hydroxy-homopregnacalciferol which is a secosterol compound that is effective in inducing the differentiation of malignant cells and is therefore useful for the treatment of malignancies such as leukemia.

REFERENCES:
Kutner, A., et al., "Novel Convergent Synthesis of Side-Chain-Modified Analogues of 1.alpha.,25-Dihydroxycholecalciferol and 1.alpha.,25-Dihydroxyergocalciferol", J. Org. Chem. 53, pp. 3450-3457 (1988).
Andrews, D. "Synthesis of 25-Hydroxy-and 1.alpha.,25-Dihydroxyvitamin D.sub.3 from Vitamin D.sub.2 (Calciferol)", Journal of Organic Chemistry, 51, pp. 4819-4828 (1986).

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