Synthesis of 1.alpha.,25-dihydroxy-24R-fluorocholecalciferol and

Details Synthesis of 1.alpha.,25-dihydroxy-24R-fluorocholecalciferol and Synthesis of 1.alpha.,25-dihydroxy-24R-fluorocholecalciferol and

1982-08-06

1987-03-24

Roberts, Elbert L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2603972, 514167, C07J 900

Patent

active

046524053

ABSTRACT:
1.alpha.,25-Dihydroxy-24R-fluorocholecalciferol and 1.alpha.,25-dihydroxy-24S-fluorocholecalciferol, analogs of 1.alpha.,25-dihydroxy-cholecalciferol which is physiologically the most active metabolite of vitamin D.sub.3, are synthesized in a multistep process from the known substance 1.alpha.,3.beta.-dihydroxyandrost-5-en-17-one. The new analogs are characterized by the ability to increase intestinal calcium transport, increase serum calcium and phosphate concentrations and to increase the deposition of these minerals in bones. These compounds will find a ready application as substitutes for natural 1.alpha.,25-dihydroxycholecalciferol in the treatment of disease states characterized by metabolic calcium and phosphate deficiencies. Exemplary of such disease states are the following: osteosclerosis, anticonvulsant treatment, osteopenia, fibrogenesis-imperfecta ossium, secondary hyperparathyrodism, hypoparathyroidism, hyperparathyroidism, cirrhosis, obstructive jaundice, drug induced metabolism, medullary carcinoma, chronic renal disease, hypophosphatemic VDRR, vitamin D-dependent rickets, sarcoidosis, glucocorticoid antagonism, malabsorption syndrome, steatorrhea, tropical sprue, idiopathic hypercalcemia and milk fever.

REFERENCES:
patent: 3847955 (1974-11-01), DeLuca
patent: 4229357 (1980-10-01), DeLuca et al.
patent: 4428946 (1984-01-01), DeLuca et al.

Affiliated with

Also associated with

Rating

Synthesis of 1.alpha.,25-dihydroxy-24R-fluorocholecalciferol and does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Synthesis of 1.alpha.,25-dihydroxy-24R-fluorocholecalciferol and, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Synthesis of 1.alpha.,25-dihydroxy-24R-fluorocholecalciferol and will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1352702