Synthesis and use of diagnostic radio-pharmaceuticals comprising

Details Synthesis and use of diagnostic radio-pharmaceuticals comprising Synthesis and use of diagnostic radio-pharmaceuticals comprising

1978-09-18

1981-03-17

Hunt, Brooks H.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

Attached to antibody or antibody fragment or immunoglobulin;...

2603434, 260335, 424 1, 424 9, 549 33, A61K 4900, A61K 4300, G01T 3348, G01T 100

Patent

active

042567270

ABSTRACT:
A process for preparing bromine-containing dyes labelled with gamma-emitting isotopes of bromine, and the product thereof which is useful as an imaging agent for the hepato-biliary system, particularly in dynamic imaging methods. The dyes prepared are from the class of triarylmethane dyes, and also from the phthalein subclass of the class of xanthene dyes, and the labelling thereof is effected with .sup.76 Br, .sup.77 Br or .sup.82 Br. The process for preparing these dyes involves reacting the non-brominated dye precursor with either .sup.76 Br.sub.2, .sup.77 Br.sub.2 or .sup.82 Br.sub.2. This is a substitution type of reaction in which a ring hydrogen is substituted by either .sup.76 Br, .sup.77 Br or .sup.82 Br.

REFERENCES:
patent: 2772290 (1956-11-01), Vodak et al.
patent: 3673410 (1972-06-01), Waite et al.
patent: 3743713 (1973-07-01), Kato et al.
patent: 3872046 (1975-03-01), Torii et al.
patent: 3959455 (1976-05-01), Ansari et al.

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