Synthesis and use of amino acid fluorides as peptide coupling re

Details Synthesis and use of amino acid fluorides as peptide coupling re Synthesis and use of amino acid fluorides as peptide coupling re

1994-08-02

1998-01-27

O'Sullivan, Peter

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

530333, 530334, 530335, 530336, 530337, 530338, 544334, 546186, 5483001, 5483401, 5483431, 5483471, 548495, 548496, 548497, 548523, 548530, 552104, 560 30, 560161, 562553, 562845, 562849, 562851, 562852, 564 1, 564245, 564433, 564442, 564510, C07D23302, C07D20702, C07C25714, C07C25718

Patent

active

057124183

ABSTRACT:
The present invention is directed to the process of preparing a peptide comprising reacting a first amino acid or peptide with an amino acid fluoride of the formula: ##STR1## or the acid fluoride salts thereof wherein BLK is an N-amino protecting group
AA is an amino acid residue and
X is H or a protecting group useful,
and the first amino and peptide have a free amino group and a blocked carboxy end.

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