Synthesis and resolution of propionic acid derivatives

Details Synthesis and resolution of propionic acid derivatives Synthesis and resolution of propionic acid derivatives

1996-11-05

1998-05-12

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

C07C 6976

Patent

active

057507643

ABSTRACT:
A process for the production of disubstituted propionic acid derivatives which are intermediates in the synthesis of .alpha.-arylpropionic acids such as naproxen, involves the reaction of a naphthalene derivative such as 2-methoxynaphthalene, with an alkylating agent such as an alkyl pyruvate in the presence of a catalyst, and then dehydrating and hydrogenolising, or directly hydrogenolising, or derivatising and then hydrogenolising the product thereof, to produce the desired compound.

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Qu-Ming Gu et al.; "A Facile Enzymatic Resolution Process for the Preparation of (+)--S--2--(6--Methoxy--2--Naphthyl) Proprionic Acid (Naproxen)"; Tetrahedron Letters, 1986, pp. 1763-1766, vol. 27, No. 16; Pergamon Press Ltd., Great Britain.

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