Synthesis and purification of [R-(R*,R*)]-5-[2-[5-(3-chloro-phen

Details Synthesis and purification of [R-(R*,R*)]-5-[2-[5-(3-chloro-phen Synthesis and purification of [R-(R*,R*)]-5-[2-[5-(3-chloro-phen

1994-06-06

1995-10-24

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D31744

Patent

active

054611636

ABSTRACT:
The invention relates to a process improvement for making [R-(R*,R*)]-5-[2-[5-(3-chlorophenyl)-2-oxo-3-oxazolidinyl]propyl]-1,3-benz odioxole-2,2-dicarboxylic acid dimethyl ester an intermediate used in the synthesis of beta-3 agonist, [R-(R*,R*)]-5-[2-[5-(3-chlorophenyl)-2-hydroxyethyl]amino]propyl]-1,3-benz odioxole-2,2-dicarboxylic acid disodium salt.

REFERENCES:
patent: 5061727 (1990-05-01), Bloom et al.
patent: 5106867 (1992-04-01), Bloom et al.
patent: 5151439 (1992-09-01), Bloom et al.
Bloom et al. Chem. Abstr. vol. 117 entry 131102 (1992).

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