Synthesis and method of use for 2, 4 diaminoquinazoline

Details Synthesis and method of use for 2, 4 diaminoquinazoline Synthesis and method of use for 2, 4 diaminoquinazoline

1987-09-18

1989-04-04

Hollrah, Glennon H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Para-n-benzene - sulfoxy-n containing doai, and said benzene...

514156, 514157, 514158, 514260, 544291, A61K 31505, C07D23995

Patent

active

048187534

ABSTRACT:
Compounds of the formula ##STR1## wherein R.sup.1 is H, methyl, ethyl, or chloro and R.sup.2 is hydrocarbyl of 1-12 C are useful as antifungal agents. Compounds of this series wherein R.sup.2 is 7-12 C are novel. A new synthetic method for the compounds is also described.

REFERENCES:
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patent: 4677219 (1987-06-01), Berman et al.
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Hitchings, et al., (III), "Chemical Abtracts", vol. 57, 1962, Col. 16633g.
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Modest, et al., "Chemical Abstracts", vol. 63, 1965, Col. 5639f.
Castaldo, R. A ., et al., Antimicrob. Agents and Chemotherapy 15:81-86 (1979).
DeGraw, J., et al., J. Med. Chem. 17:762-764 (1974).
Colwell, W. T., et al., Chemistry and Biology of Pteridines, Kisliuk/Brown, eds., Elsevier, North Holland Inc., pp. 215-218 (1979).
Hariri, A. R., et al., Proc. Soc. Exp. Biol. Med. 151:173-176 (1976 ).

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