Synthesis and isolation of N-(aryl or heteroaryl)-alkyl-N-hydrox

Details Synthesis and isolation of N-(aryl or heteroaryl)-alkyl-N-hydrox Synthesis and isolation of N-(aryl or heteroaryl)-alkyl-N-hydrox

1998-09-25

2000-06-27

McKane, Joseph K.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549 75, 549467, 549469, 549493, 564 56, 564 60, 564 61, C07D33356, C07D30778, C07D30702, C07D27300

Patent

active

060808748

ABSTRACT:
The present invention provides a simple, 1-step process for preparing a N-(aryl or heteroaryl)-hydroxyurea comprising reacting the corresponding alcohol, ester or ether with hydroxyurea and acid. This reaction is particularly useful for preparing a benzo[b]thienyl substituted N-hydroxyurea of formula: ##STR1## from compound 1: ##STR2## by reacting compound 1 with hydroxyurea and acid. R.sup.1 is selected from the group consisting of hydrogen, 1-6 carbon alkyl, 1-6 carbon alkoxy, and halogen; R.sup.2 is an 1-4 carbon alkyl; and R.sup.3 is selected from the group consisting of hydrogen, acyl, methyl, ethyl and mixtures thereof. Additional steps to isolate the pure bulk product follow.

REFERENCES:
patent: 4873259 (1989-10-01), Summers, Jr. et al.
patent: 4992464 (1991-02-01), Brooks et al.
patent: 5026729 (1991-06-01), Brooks et al.
patent: 5175183 (1992-12-01), Brooks et al.
patent: 5185363 (1993-02-01), Brooks et al.
patent: 5250565 (1993-10-01), Brooks et al.
patent: 5288896 (1994-02-01), Capiris et al.
patent: 5292900 (1994-03-01), Bahsa et al.
patent: 5663368 (1997-09-01), Flisak et al.
A.O. Stewart, et al., J. Org. Chem., 1992, 57, 5020-5023.

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