Synthesis and immunogenicity of rotavirus genes using a baculovi

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

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4352351, 4353201, 4351723, 935 32, 935 57, 935 65, C12N 701, C12N 1546, C12N 1580, C12P 2102

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058405410

ABSTRACT:
A method to express rotavirus genes in a baculovirus system. Different clones are used to express rotavirus genes for all of the viral proteins. These proteins are isolated in their native conformation. Some of these proteins show antigenic properties and are used to vaccinate human, agricultural animals and pet animals against diarrheal disease. The antigenic proteins are also used to detect the presence of the viral infectious agent either by themselves or in conjunction with antibodies produced against the antigenic proteins.

REFERENCES:
Summers, M.D. et al. 1985. In: Genetically Altered Viruses and the Environment, ed. B. Fields, 22 Banbury Rport, Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y., pp. 319-331.
Ward, C.W. et al. 1985. Virology, vol. 144, pp. 328-336.
Both, G.W. et al. 1983. Journal of Virology, vol. 48, pp. 335-339.
Okada, Y. et al 1984. Journal of Virology, vol. 51, pp. 856-859.

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