Synthesis and characterization of N-bromoacetyl-3,3'5-triiodo-L-

Details Synthesis and characterization of N-bromoacetyl-3,3'5-triiodo-L- Synthesis and characterization of N-bromoacetyl-3,3'5-triiodo-L-

1990-09-10

1992-12-08

Dees, Jose G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

C07C22936, C07C22934

Patent

active

051699842

ABSTRACT:
A method for synthesizing N-bromoacetyl-3,3',5-triiodo-L-thyronine which involves subjecting 3,3', 5-triiodo-L-thyronine to a one-step bromacetylation reaction wherein 3,3', 5-triiodo-L-thyronine and bromoacetyl bromide are refluxed together in a solution of ethyl acetate. After formation the N-bromoacetyl-3,3'-triiodo-L-thyronine is purified by fractionation utilizing high speed countercurrent chromatography. Labeled N-bromoacetyl-3,3'-5-triiodo-L-thryonine may be made by a one-step bromacetylation reaction by reducing either [.sup.125 I]T.sub.3 or [.sup.14 C]T.sub.3 with bromoacetyl bromide.

REFERENCES:
patent: 4430216 (1984-02-01), Ito
Cheng et al, J. Biol. Chem., 252(17), 6076-6081, 1977.
Matsuura et al, J. Am. Chem. Soc., 81, 871-878, 1959.

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