Synthesis and biological activity of [D-Thr.sup.2, .DELTA..sup.3

Details Synthesis and biological activity of [D-Thr.sup.2, .DELTA..sup.3 Synthesis and biological activity of [D-Thr.sup.2, .DELTA..sup.3

1979-05-09

1980-12-09

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424177, C07C10352, A61K 3700

Patent

active

042383900

ABSTRACT:
The present disclosure is directed to the synthesis and biological activity of [D-Thr.sup.2, .DELTA..sup.3 Pro.sup.5 ]-enkephalinamide. The subject compound is useful as an agent for the inhibition of diarrhea and also exhibits analgesic activity.

REFERENCES:
Vizi; E. S., Biological Abst. 1978, p. 4879.
Szekely; J. I., Biological Abst. 1978, p. 23486.
Yamashiro et al., Biochem. and Biophys. Res. Commun. 78, 1977, 1124-1129.
Bajusz et al., Biochem. and Biophys. Res. Commun., 84, 1978, 1045-1053.

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