Synthesis and antitumor activity of 2,4,5-trisubstituted-pyrrolo

Details Synthesis and antitumor activity of 2,4,5-trisubstituted-pyrrolo Synthesis and antitumor activity of 2,4,5-trisubstituted-pyrrolo

1977-11-21

1979-02-20

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

424180, 536 26, C07H 1700, C07H 1906, A61K 3170

Patent

active

041408519

ABSTRACT:
Certain trisubstituted pyrrolopyrimidine nucleosides are prepared from toyocamycin and have shown antitumor activity against L1210 and P388 murine leukemia. The particular compounds of interest are selected from the following structural formula: ##STR1## where X is halo

REFERENCES:
cheng, C. S., et al., J. Am. Chem. Soc., 98:7870, (1976).
Henshaw, B. C., J. Org. Chem., 35:236, (1970).

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