Synthesis and antimicrobial activity of novel dicationic...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C514S438000, C514S471000, C548S577000, C549S071000, C549S491000, C546S258000, C546S284100

Reexamination Certificate

active

10791425

ABSTRACT:
The present invention relates to novel 2,5-bis{[alkyl (or aryl) imino]aminophenyl}furans and thiophenes of the general formulain which R1, R2, R3and R4are each independently selected from the group consisting of H, alkyl, alkoxy, halide, and alkylhalide groups; R5is H, alkyl or aryl; R6is H, alkyl, aryl, or NR7R8, in which R7and R8are each independently selected from the group consisting of H, alkyl and aryl; and X is O, S or NR9, in which R9is H or alkyl, and to the use of such compounds.

REFERENCES:
patent: 2002/0156098 (2002-10-01), Werbovetz et al.
patent: 2004/0235927 (2004-11-01), Boykin et al.
patent: WO 02/36588 (2002-05-01), None
patent: WO02/36588 (2002-05-01), None
patent: WO 02/055025 (2002-07-01), None
patent: WO 03/017994 (2003-03-01), None
Kumar et al., Palladium Catalyzed Cross-Coupling Reactions for the Synthesis of 2.5-disubstitutedfurans,Hetercyclic Comm.5:301-304 (1999).
Ling et al. Models for Intramolecular Exchange in Organic π-Conjugated Open-Shell Systems: 3-Nitrenophenyl and 4-Nitrenophenyl Units Connected by 2,5-Furandiyl, 2,5-Thiophenediyl, and 2,5-Pyrrolediyl Nonalternant Exchange Linkers,J. Am. Chem. Soc.116:8784-8792 (1994).
Shearer et al., S-2-Naphthylmethyl Thioacetimidate Hydrobromide: A New Odorless Reagent for the Mild Synthesis of Substituted Acetamidines,Tetrahedron Lett.38:179-182 (1997).
Stephens, et al., Diguanidino and “Reversed” Diamindino 2,5-Diarylfurans asn Antimicrobial Agents,J. Med. Chem44:1741-1748 (2001).
Poeta et al., “In Vitro Antifungal Activities of a Series of Dication-Substituted Carbazoles, Furans, and Benzimidazoles”,Antimicrobial Agents and Chemotherapy, 42(10): 2503-2510, Oct. 1998.
Steck et al., “Leishmania donovani, Plasmodium berghei, Trypanosoma rhodesiense: Antiprotozoal Effects of Some Amidine Types”,Experimental Parasitology, 52: 404-413, 1981.
Poeta et al., “Structure-In Vitro Activity Relationships of Pentamidine Analogues and Dication-Substituted Bis-Benzimidazoles as New Antifungal Agents”,Antimicrobial Agents and Chemotherapy, 42(10): 2495-2502, Oct. 1998.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Synthesis and antimicrobial activity of novel dicationic... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Synthesis and antimicrobial activity of novel dicationic..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Synthesis and antimicrobial activity of novel dicationic... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3741203

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.