Synthesis and antimalarial activity of...

Details Synthesis and antimalarial activity of... Synthesis and antimalarial activity of...

2007-08-07

2007-08-07

Tucker, Zachary C. (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C544S247000

Reexamination Certificate

active

10971846

ABSTRACT:
The invention relates to derivatives of pyrroloquinazolinediamine, more specifically derivatives of 7-(substituted)-7H-pyrrolo[3,2-F] quinazoline-1,3-diamines that are non-toxic and are also effective in the treatment of malaria, includingP. falciparumandP. vivaxstrains. The derivatives are certain carbamate derivatives, succinimide derivatives, alkylcarboxamides derivatives and acetamide derivative, phthalimides, alkylamines and all other amide and imide derivatives and their 1-hydroxy analogs. The derivatives of the present invention are also soluble in common organic solvents to facilitate the purification in a large scale synthesis of the composition.

REFERENCES:
patent: 4118561 (1978-10-01), Ledig
patent: 4208520 (1980-06-01), Ledig et al.
patent: WO/02/068425 (2002-09-01), None
Ho-Sam Ahn, et al., Structure-Activity Relationships of Pyrroloquinazolines as Thrombin Receptor Antagonists, Biooganic & Medicinal Chemistry Letters 9 (1999) 2073-2078.

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