Synthesis and anti-leukemic activity of alkyl-1-(.beta.-D-ribofu

Details Synthesis and anti-leukemic activity of alkyl-1-(.beta.-D-ribofu Synthesis and anti-leukemic activity of alkyl-1-(.beta.-D-ribofu

1988-11-02

1990-05-15

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C07H 19056

Patent

active

049259300

ABSTRACT:
A novel class of alkyl-1-(.beta.-D-ribofuranosyl)[1,2,4]triazole-3-carboximidates of the formula: ##STR1## wherein R.sub.1 is methyl or ethyl and R.sub.2 is .beta.-D-ribofuranosyl, are useful as anti-leukemic agents.

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Ganesh D. Kini, et al., J. Med. Chem., 32, 1447 (1989).
Witkowski et al., J. Med. Chem., 16, 935 (1973).
Riley et al., J. Heterocyclic Chem., 34, 955 (1987).

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