Syntheses of fluorescein compounds with excess resorcinol as a s

Details Syntheses of fluorescein compounds with excess resorcinol as a s Syntheses of fluorescein compounds with excess resorcinol as a s

1995-09-27

1997-06-10

Owens, Amelia

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D31182

Patent

active

056377339

ABSTRACT:
A process for the manufacture of fluorescein compounds suitable for conversion to FDA certified dyes is described. The fluorescein compounds, and in particular fluorescein (also known as Solvent Yellow 94 or D&C Yellow No.7) and 3,4,5,6-tetrachlorofluorescein, are made by a process involving the condensation of a phthalic anhydride with several molar excess of a resorcinol, the resorcinol being employed not only as a reactant, but also as a solvent for the reaction. This process also can employ the unreacted resorcinol and any intermediates or by-products from the condensation reaction as a reactant and as a solvent in subsequent condensation reactions.

REFERENCES:
patent: 1931049 (1933-10-01), Woods et al.
patent: 1965842 (1934-07-01), Kranz
patent: 2355359 (1944-08-01), Bainbridge et al.
patent: 2980696 (1961-04-01), Korbl
patent: 4933471 (1990-06-01), Lee
patent: 5066580 (1991-11-01), Lee
Khanna, PL et al CA 95:38669 (1981).
On The Theory of Indicators and the Reactions of Phthaleins and their Salts, S.F. Acree and E. Slagle, JACS, 1909, 37, pp. 115-147.
Organic Reactions with Boron Fluoride, J.F. McKenna and F.J. Sowa, JACS, 1938, 60, pp. 124-125.
Detection and Determination of Starting Materials and Uncombined Intermediates of Organic Synthesis as well as Subsidiary Dyes Remaining in Cosmetic Coal-Tar Dyes by High Performance Liquid Chromatography (II), Y. Ito, et al., J. Soc. Cosmet. Chem. Japan, 1983.
Complementary Use if Counter-Current Chromatography and Preparative Reversed-Phase High-Performance Liquid Chromatography in the Separation of a Synthetic Mixture of Brominated Tetrachlorofluoresceins, A. Weiss, et al., Journal of Chromatography, 607 (1992), pp. 47-53.
Fluorescein and Some of its Derivatives, W.R. Orndorff and A.J. Hemmer, JACS, 1927, 49, pp. 1272-1280.
2,4-Dihydroxybenzoyltetrachloro-o-Benzoic Acid and 2,3,4-Trichloro-6-Hydroxyxanthone-1-Carboxylic Acid and Some of their Derivatives, W.R. Orndorff and W.A. Adamson, JACS, 1918, 40, pp. 1235-1237.
Tetrachlorofluorescein and Some of its Derivatives, W.R. Orndorff and E.F. Hitch, JACS, 1914, 36, pp. 680-725.

Affiliated with

Also associated with

Rating

Syntheses of fluorescein compounds with excess resorcinol as a s does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Syntheses of fluorescein compounds with excess resorcinol as a s, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Syntheses of fluorescein compounds with excess resorcinol as a s will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-765806