Synovial phospholipases

Details Synovial phospholipases Synovial phospholipases

1988-07-06

1991-05-28

Schwartz, Richard A.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

4351721, 4353201, 4352523, 536 27, 935 14, C12N 920, C12N 1555, C07H 1512

Patent

active

050195085

ABSTRACT:
Mammalian synovial phospholipase A.sub.2 (sPLA.sub.2) enzymes are provided, as well as DNA constructs encoding these enzymes, methods of producing the enzymes recombinantly, and antibodies thereto. Therapeutic methods employing anti-synovial phospholipase antibodies are also provided, in addition to diagnositc methods and other applications of sPLA.sub.2.

REFERENCES:
Tanaka et al. Gene 64:257-264 (1988).
Geus et al. Nucleic Acids Research 15(9):3743-3759 (1987).
O'Hara et al., (1976) J. Biochem. 99:733-739.
Dufton et al., (1983) Eur. J. Biochem. 137:537-544.
Grataroli et al., (1982) Eur. J. Biochem. 122:111-117.
Reneseder et al., (1985) J. Bio. Chem. 260:11627-11634.
Pruzanski et al., (1986) J. Invest. Dermatol. 86:380-383.
Verger et al., (1982) Biochem. 21:6883-6889.
Gray et al., (1982) Can. J. Biochim. 60:108-117.
DeWinter et al., (1982) Biochim. Biophys. Acta 712:332-341.
Franson et al., (1982) Lung 160:275-284.
Garcia et al., (1975) Biochim. Biophys. Res. Comm. 64:128-135.
Sahu et al., (1977) Biochim. Biophys. Acta 489:307-317.
Verger et al., (1982) Biochem. 21:6883-6889.
Teramoto et al., (1983) J. Biochim. 93:1353-1360.
Trotter et al., (1986) Neurochem. Res. 11:349-361.
Lanni et al., (1981) Biochim. Biophys. Acta 658:54-63.
Vadas et al., (1980) Life Sciences 26:1721-1729.
Vadas (1981) Nature 293:583-585.
Wightman et al., (1981) Biochim. J. 200:441-444.
Franson et al., (1973) Biochim. Biophys. Acta 296:365-373.
Traynor et al., (1981) Biochim. Biophys. Acta 665:571-577.
Franson et al., (1977) Biochim. J. 167:839-841.
Kramer et al., (1978) Biochim. Biophys. Acta 507:381-394.
Chang et al., (1986) J. Immunol. 136:1283-1287.
Jesse et al., (1979) Biochim. Biophys. Acta 575:467-470.
Apitz-Castro et al., (1979) Biochim. Biophys. Res. Comm. 91(1): 63-71.
Van Den Bosch (1980) Biochim. Biophys. Acta 604:191-246.
Vadas et al., (1984) Adv. Inflammation Res. 7:51-59.
Vadas et al., (1981) Nature 293:583-585.
Silverman et al., American Rheumatism Association: 51st Annual Scientific Meeting (9-13 Jun. 1987, Washington, D. C.).
Hayakawa et al., (1988) J. Biochem. 103:263-266.
Dutilh et al., (1981) J. Sci. Food Agricul. 32:451-458.
Mazeaud et al., (1976) J. Fish Res. Board Can. 33:1297-1303.
Hara et al., (1988) J. Biochem. 104:326-328.
Matsuda et al., (1987) Res. Commun. in Chem. Path. Pharmacol. 58(2):281-284.
Tojo et al., (1988) J. Biol. Chem. 263(12):5724-5734.
Ono et al., (1988) J. Biol. Chem 263(12):5732-5738.
Franson et al., (1978) J. Lipid Res. 19:18-23.
Stefanski et al., (1986) J. Biochem. 100:1297-1303.
Vadas et al.-(1985) Life Sciences 36:579-1303.
Pruzanski et al., (1985) Journal of Rheumatology 12(2):211-216.
Forst et al., (1986) Biochemistry 25:8381-8385.
Hayakawa et al., (1987) J. Biochem. 101-1311-1314.
Chang et al., (1987) J. Biochem. 102:147-154.
Nakaguchi et al., (1986) Enzyme 35:2-12.
Loeb et al., (1986) Journal of Biological Chemistry 261(23): 10467-10470.
Kramer et al., (1986) Biochim. Biophys. Acta 878:394-403.
Castle et al., (1981) Biochim. Biophys. Acta 666:259-274.
Gattaz et al., (1987) Biol. Psychiatry 22:421-426.
Horigome et al., (1987) J. Biochem. 101:625-631.
Bomalaski et al., (1986) Arthritis and Rheumatism 29(3):312-318.
Takano et al., (1987) Scand. J. Gastroenterol. 22:577-584.
Fawzy et al., (1987) Inflammation 11(4):389-400.
Chang et al., (1986) J. Biochem. 100:1099-1101.
Selihamer et al., (1986) DNA 5(6):519-527.
Huruki et al., (1986) J. Biochem. 99:99-109.
Han et al., (1987) Biochemistry 26:1617-1625.

Affiliated with

Also associated with

Rating

Synovial phospholipases does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Synovial phospholipases, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Synovial phospholipases will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-35706