Synergistic tumor therapy with combinations of biologically acti

Details Synergistic tumor therapy with combinations of biologically acti Synergistic tumor therapy with combinations of biologically acti

1990-05-22

1992-11-24

Kepplinger, Esther L.

Drug, bio-affecting and body treating compositions

Lymphokine

5303888, 435 7021, 4351722, A61K 39395, C07K 1528, C12P 2108, C12N 1502

Patent

active

051659220

ABSTRACT:
The present invention relates to the use of combinations of antibody therapy and chemotherapy in the treatment of malignant disease. More particularly, the invention relates to novel methods of treating patients who have malignant disease and who have shown an unresponsiveness to treatment with standard chemotherapy regimens by administering to those patients (i) an antibody that binds to the malignant cells of the patient and (ii) a chemotherapeutic agent. According to particular embodiments of the invention, anti-glycolipid antibodies are administered to patients who are subsequently treated with standard chemotherapy regimens.

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