Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1995-06-05
1998-10-13
Weddington, Kevin E.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 19, 5142345, 514253, 514322, 514374, 514381, 514394, A61K 3800, A61K 31535, A61K 31495, A61K 3141
Patent
active
058212329
ABSTRACT:
This invention relates to compositions and methods for achieving a therapeutic effect such as lowering blood pressure and treating congestive heart failure in a mammal. More specifically, this invention relates to synergistic compositions comprising amounts of at least two therapeutic agents selected from the group consisting of a renin inhibitor, an angiotensin I converting enzyme inhibitor and an angiotensin II antagonist, which inhibitors and antagonists are present in amounts sufficient to cause synergistic therapeutic effects such as lowering blood pressure and treating congestive heart failure in a mammal. Further, this invention relates to methods for achieving synergistic therapeutic effects such as lowering blood pressure and treating congestive heart failure in a mammal which methods comprise administering to said mammal, either sequentially in any order or simultaneously, amounts of at least two therapeutic agents selected from the group consisting of a renin inhibitor, an angiotensin I converting enzyme inhibitor and an angiotensin II antagonist, in amounts sufficient to achieve a synergistic therapeutic effect.
REFERENCES:
patent: 4046889 (1977-09-01), Ondetti et al.
patent: 4355040 (1982-10-01), Furukawa et al.
patent: 4374829 (1983-02-01), Harris et al.
patent: 4749688 (1988-06-01), Haslanger et al.
patent: 4814342 (1989-03-01), Hoover et al.
patent: 4880804 (1989-11-01), Carini et al.
patent: 4895834 (1990-01-01), Hudspeth et al.
patent: 4962105 (1990-10-01), Ksander et al.
Blaine, E. H. et al., Hypertension 7, Suppl. 1:1-66 to 1-71 (1985).
Mento, P. F. et al, Hypertension 13:741-748 (1989) (C.A. III (9) 28 Aug. 1989, Abst. No. 70591c).
Oldham, A. A. et al., J. Cardiovasc. Pharmacol. 6:672-677 (1984).
Pals, D. T. et al., Clin. and Exper. Hyper.--Theory and Practice A13:425-436(1991).
Smith III, S. G. et al., Hypertension 9:150-156 (1987).
Sweet, C. S. et al., J. Cardiovasc. Pharmacol. 6:1067-1075 (1984).
Timmermans, P. B. M. W. M. et al. Blood Vessels 27:295-300 (1990).
Tree, M. et al., J. Hypertension 7:S51-S55 (1989).
Wong, P. C. et al., J. Pharmcology and Experimental Therapeutics 252:719-725 (1990).
Wood, J. M. et al., J. Cardiovasc. Pharmacol. 16(Suppl 4):S60-S64 (1990).
Wood, J. M. et al., J. Hypertension 7:S37-S42 (1989).
Wood, J. M. et al., Journal of Pharmacology and Experimental Therapeutics 253:513-517 (1990).
Benson Gregg C.
Pfizer Inc.
Richardson Peter C.
Weddington Kevin E.
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