Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1974-08-07
1977-01-25
Goldberg, Jerome D.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
424266, 424330, A61K 3144
Patent
active
040052079
ABSTRACT:
The specification relates to an oral composition for the treatment of mycobacterioses, such as the treatment of leprosy and tuberculosis, containing an effective amount of isonicotinic acid hydrazide (international non-proprietary name isoniazid, designated herein as INH), an effective amount of 2-propyl-thioisonicotinic acid amide (prothionamide designated herein as PTH) and/or 2-ethyl-thioisonicotinic acid amide (ethionamide designated herein as ETH) and an effective amount of a sulfone and/or a sulfonamide with sustained activity. Suitable sulfones and sulfonamides with sustained activity, among others, are 4,4'-diaminodiphenyl-sulfone designated herein as DDS, sulfamethoxypyridazine and the like, as well as combinations of sulfones with sulfonamides, such as trimethoprimsulfonamides.
REFERENCES:
the Merck Index, 8th ed., Merck & Co., Inc., 1968, pp. 321, 586 and 879.
Freerksen et al., Arzweimittel-Forschowg 22, 1235-1242 (1972).
Goldberg Jerome D.
Saarstickstoff-Fatol GmbH
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