Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...
Patent
1986-09-12
1989-11-14
Robinson, Douglas W.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Radical -xh acid, or anhydride, acid halide or salt thereof...
514567, 514614, 514654, A61K 31195, A61K 3116, A61K 31135
Patent
active
048808334
ABSTRACT:
The invention relates to a synergistic pharmaceutical composition, which comprises as an active ingredient a combination of 1-phenylalanine and (-)-deprenyl [(-)-N-(1-phenylisopropyl)-N-methyl-N-propinylamine hydrochloride] and optionally carbidopa [3-(3,4-dihydroxyphenyl)-2-hydrazino-2-methyl-propionic acid monohydrate] or benzerazide [N-(DL-seryl)-N'-( 2,3,4-trihydroxybenzyl)-hydrazine] in association with conventional inert, non-toxic solid or liquid pharamaceutical carriers. The invention further relates to the preparation of these compositions and to the use thereof for the treatment of depressive symptoms.
REFERENCES:
patent: 3362879 (1968-01-01), Udenfriend et al.
patent: 3485926 (1969-12-01), Schuler et al.
patent: 4156017 (1979-05-01), Kruger et al.
patent: 4355044 (1982-10-01), Heller
patent: 4377595 (1983-03-01), Wurtman
patent: 4431670 (1984-02-01), Heller
The Merck Index, 9th ed., abstract No. 7071, (1976).
Chem. Abst., #98:214619f, (1983).
Lysine, Tryptophan and Other Amino Acids, Garrison, Robert Jr. .COPYRGT.1982, pp. 1-9.
L-Deprenyl plus L-Phenylalanine in the Treatment of Depression, Birkmayer et al., J. Neural, Transmission, 59, pp. 81-87, (Springer-Verlag 1984);
Biochemical Effects of Deprenyl, Liebowitz et al, Physchopharmacology Bulletin, vol. 19, No. 3, pp. 337-339, (1983).
Symptoms of Atypical Depression as a Predictor of Response to L-Deprenyl, Mann et al, Psychopharmacology Bulletin, vol. 19, No. 3, pp. 333-335, (1983).
Clinical Efficacy of Deprenyl, a Specific Inhibitor of MAO.sub.B ; A Double-Blind Placebo Study of L-Deprenyl in Affective Disorders; Mendlewicz et al., Physicopharmacology Bulletin, vol. 19, No. 3, pp. 329-332, (1983).
Chemical Abstracts 100:168070e;
Chemical Abstracts 97:49652f.
Birkmayer Walter
Ecsery Zoltan
Kalloy Katalin
Knoll Jozsef
Marton Jeno
Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Rt
Dubno Herbert
Henley III Raymond J.
Myers Jonathan
Robinson Douglas W.
LandOfFree
Synergistic pharmaceutical compositions, their production and us does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Synergistic pharmaceutical compositions, their production and us, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Synergistic pharmaceutical compositions, their production and us will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1853255